DKM活性分子 Dynamic Key Med 活性化合物活性分子平台 7*24在线

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Mabs In Vivo

PD-1/PD-L1

Angiogenesis

Apoptosis

Natural product

Cancer

Epigenetics

Stem Cells

ADC Related

DKM活性化合物

荧光素衍生物AkaLumine hydrochloride，CAS#2558205-28-8,对重组萤火虫荧光素酶（Fluc）的米氏常数（Km）为2.06 μM。其近红外发射特性支持高穿透深度的组织成像，显著提升靶标信噪比，使活体动物模型中极低剂量下的高精度、无创生物发光监测成为可能。

AkaLumine盐酸盐是荧光素类似物，Km为2.06 μM，具近红外发射峰，支持深层组织成像，提升检测灵敏度，实现动物模型中低浓度、高精度、非侵入性生物发光成像。

DKM活性化合物 9小时前

2722

DKM活性化合物

RMC系列小分子化合物简介:RMC-9805,RMC-5127,RMC-5552,RMC-6291,RMC-7977,RMC-0708,RMC-8839.

Revolution Medicines 公司截至2026年4月共布局7款RAS靶向小分子：RMC-6236（泛RAS，III期）、RMC-9805（G12D，II/III期）、RMC-6291（G12C，II期）、RMC-5127（G12V，I期）、RMC-7977（泛RAS三复合物，临床前）、RMC-0708与RMC-8839（Q61H、G13C，均处发现阶段）。

DKM活性化合物 10小时前

5426

DKM活性化合物

MYLS22是一种靶向视神经萎缩1（OPA1）的选择性抑制剂，兼具抗血管生成与抗肿瘤功效。

MYLS22是靶向OPA1的高选择性小分子抑制剂，具抗血管生成与抗癌活性；纯度≥99%，稳定，可诱导线粒体碎片化并增强促凋亡效应。

DKM活性化合物 11小时前

447

DKM活性化合物

高效PKC抑制剂Go6976（PD406976），CAS号136194-77-9，兼具强效JAK2与Flt3抑制活性

Go 6976是高选择性PKCα/β1抑制剂（IC₅₀分别为2.3/6.2 nM），兼抑FLT3、JAK2等激酶；具抗增殖、促凋亡、抑侵袭及改善代谢与器官损伤作用，广泛用于信号研究与抗癌探索。

DKM活性化合物 2天前

1142

DKM活性化合物

盐酸阿霉素（Doxorubicin Hydrochloride）：生物活性解析、实验操作指南与溶液配制规范

Doxorubicin (Adriamycin) HCl阿霉素盐酸盐为蒽环类抗肿瘤抗生素，通过嵌入DNA并抑制拓扑异构酶II发挥细胞毒性；适用于体外细胞（如HeLa）及体内PC3异种移植瘤模型研究，常规配制用DMSO或生理盐水。

DKM活性化合物 2天前

742

DKM活性化合物

肠道微生物代谢与合成生物学研究的关键试剂——高纯度即用型苯乙酰辅酶A（Phenylacetyl CoA），CAS No. 7532-39-0

Phenylacetyl-CoA 是苯乙酸代谢活化的关键中间体，广泛应用于酶学分析、代谢流追踪及合成生物学。我司产品纯度≥98%，冷链运输、NMR验证，小规格分装，确保高活性与稳定性。

DKM活性化合物 2天前

5249

DKM资讯

全部

PI3K/Akt/mTOR
- Akt
- AMPK
- ATM/ATR
- PI3K
- PDK
- FOXO
- MELK
- mTOR
- GSK-3
- PDK-1
- PI4K
- PIKfyve
- PIN1
- PTEN
- RSK
Epigenetics
- AMPK
- Aurora Kinase
- DNA Methyltransferase/DNA甲基转移酶
- Epigenetic Reader Domain/表观遗传阅读框
- FTO
- HDAC/组蛋白去乙酰化酶
- HES
- HIF
- Histone Acetyltransferase/组蛋白乙酰转移酶
- Histone Demethylase/组蛋白甲基转移酶
- Histone Methyltransferase/组蛋白甲基转移酶
- JAK
- MBD-containing protein
- METTL3
- MicroRNA/微RNA
- PAD
- PARP
- Pim
- PKC
- PRMT
- SF3B1
- Sirtuin
- TET
Methylation/甲基化
- PRMT
- EZH2
- DNA Methyltransferase
- LSD1
- MLL
- G9a/GLP
- JMJD
- NSD
- FTO
- SETD
- DOT1
- MAT2A
- SMYD
- COMT
- WDR5
- NNMT
- HNMT
- SAM MTase
- PPMTase
Immunology & Inflammation/免疫炎症
- AIM2
- AP-1
- Arginase/精氨酸酶
- Calcineurin
- CCR
- CD19
- CD2
- CD20
- CD22
- CD276/B7-H3
- CD28
- CD28-B7
- CD3
- CD38
- CD47
- CD6
- CD73
- CD74
- CD80
- cGAS
- Complement C3
- Complement Receptor
- Complement System/补体系统
- COX/环氧化酶
- CRTH2
- CTLA-4
- CXCR
- Cyclophilin
- FAP
- FKBP
- FLAP
- FPR
- Galectin/半乳糖凝集素
- Glucocorticoid Receptor/糖皮质激素受体
- Glycoprotein VI
- GM-CSF
- Histamine Receptor/组胺受体
- HMGB
- IFNAR/干扰素受体
- IKZF Family
- IL Receptor
- others
- IRAK
- IRF3
- LAG-3
- LanC-like protein
- Legumain
- LTA4H
- LTR
- MALT1
- Mesothelin
- MIF
- Mucin
- MyD88
- NADPH Oxidase/NADPH氧化酶
- NFAT
- NLR
- NO Synthesis
- NOS
- NOT
- Nrf2
- PD-1/PD-L1
- PG Synthase
- PSMA
- Pyroptosis/焦亡
- ROS
- S100A9
- Scavenger receptor
- SIK
- SOD
- SphK
- STING
- TENT
- Thrombopoietin Receptor/血小板生成素受体
- Tim3
- TLR
- TSPO
- VISTA
- XBP1
Protein Tyrosine Kinase/PTK酪氨酸蛋白激酶
- EGFR
- VEGFR
- PDGFR
- FGFR
- FLT3
- c-Kit
- Src
- c-Met
- Bcr-Abl
- BTK
- MEK
- HER2
- ALK
- IGF-1R
- CSF-1R
- Trk receptor
- Syk
- c-RET
- FAK
- Axl
- Mertk
- DYRK
- ROS1
- Tyro3
- Pyk2
- RON
- Ephrin receptor
- DDR
- Tie-2
- ACK
- Insulin Receptor
- Fer kinase
Angiogenesis
- EGFR
- VEGFR
- JAK
- PDGFR
- FGFR
- Src
- FLT
- FLT3
- HER2
- HIF
- Bcr-Abl
- BTK
- ALK
- Syk
- FAK
- Hck
- VDA
- ANGPTL
Apoptosis/凋亡
- Apoptosis related/凋亡相关
- Ras
- STAT
- TNF-alpha
- Bcl-2
- Caspase
- K-Ras
- Ferroptosis
- p53
- RIP kinase
- c-RET
- MDM
- MRP
- Antifolate
- Myc
- IAP
- OXPHOS
- PD-1/PD-L1
- FKBP
- PERK
- ABC Transporter
- Thymidylate Synthase
- Heme Oxygenase
- Photosensitizer
- Pyroptosis
- Annexin A
- Survivin
- Disulfidptosis
- ASK
- PFKFB
- DAPK
- Cuproptosis
- Nur77
- Bcl-6
- PKD
- NEDD8
- Necroptosis
- TACE
- FDX1
- Fas/FasL
- cytohesin
- TRADD
- SMARCA2
- ADAM10
Autophagy/自噬
- Autophagy
- Mitophagy
- Nrf2
- CXCR
- LRRK2
- ULK
- FKBP
- Heme Oxygenase
- cGAS
- Cell wall
- LC3
- GluCls
- OGA
- Beclin
- ATTECs
ER stress & UPR/内质网应激&UPR响应
- Antioxidant
- ROS
- HSP
- JNK
- eIF
- PERK
- IRE1
- ASK
- PKR
- PDI
- ER stress
- ATF-6
JAK/STAT
- EGFR
- STAT
- Pim
- JAK1
- JAK2
- JAK3
- Tyk2
MAPK
- Ras
- ERK
- p38 MAPK
- K-Ras
- Raf
- JNK
- MEK
- S6 Kinase
- MAP4K
- Mixed Lineage Kinase
- TAK1
- MAPKAPK2
- ASK
- MNK
- TOPK
- KLF
- p53
Cytoskeletal Signaling细胞骨架
- Akt
- Microtubule Associated
- Wnt/beta-catenin
- PKC
- HSP
- Bcr-Abl
- Integrin
- FAK
- ROCK
- Kinesin
- PAK
- Actin
- MLCK
- Dynamin
- MPS1
- PORCN
- KSP
- Gap-Junction
- Cardiac Myosin
- TACC3
- Piezo Channel
- Myosin
- Tight Junction Protein
Cell Cycle细胞周期
- DNA/RNA Synthesis
- CDK
- Ras
- Microtubule Associated
- K-Ras
- HSP
- Aurora Kinase
- Casein Kinase
- Serine/threonin kinase
- Rho
- ROCK
- Chk
- Kinesin
- PLK
- Myc
- DHFR
- eIF
- PD-1/PD-L1
- PAK
- PERK
- DYRK
- AP-1
- MPS1
- p21
- Wee1
- RUNX
- LIM kinase
- BMI-1
- PP2A
- Nur77
- PFKFB
- TOPK
- Cell Cycle Arrest
- Haspin Kinase
- DOCK
- TACC3
- CDK4/6
- APC
- FOXM1
- Cyclin
- Choline kinase
- Mad2
- KRas inhibitor
TGF-beta/Smad
- PKC
- TGF-beta/Smad
- Bcr-Abl
- ROCK
DNA Damage/DNA Repair/DNA损伤/修复
- DNA/RNA Synthesis
- HDAC
- Topoisomerase
- PPAR
- PARP
- Sirtuin
- Casein Kinase
- ATM/ATR
- MDM
- DNA-PK
- DNA alkylator
- DHFR
- Nucleoside Analog/Antimetabolite
- eIF
- Telomerase
- CRISPR/Cas9
- Thymidylate Synthase
- RAD51
- Alkylating Agent
- RNR
- NUDIX
- BMI-1
- LIM kinase
- OGG1
- MTH1
- G-quadruplex
- High-mobility Group
- FENs
- SMN
- Pax
- WRN
Stem Cells & Wnt/干细胞&Wnt通路
- JAK
- STAT
- ERK
- Wnt/beta-catenin
- TGF-beta/Smad
- GSK-3
- Casein Kinase
- ROCK
- Hedgehog/Smoothened
- PKA
- Notch
- Secretase
- PORCN
- OCT
- KLF
- Fascin
- Stemness kinase
- SFRP
Hippo
- TEAD
- YAP
- MAP4K
- LATS
- MST
Metabolism代谢
- 11β-HSD
- 15-PGDH
- 2OG Oxygenase
- 3-PGDH
- 3MST
- 6PGD
- ACAT
- ACC
- Acetolactate Synthase
- ACMSD
- Aconitate hydratase
- ACS
- Adenosine Deaminase/腺苷脱氨酶
- Adenosylhomocysteinase
- ADP-ribosyltransferase
- AhR
- AKR
- ALDH
- Aldose Reductase/醛糖还原酶
- Aminopeptidase/氨肽酶
- Antifolate/抗叶酸
- AO
- ApoE
- Arginase/精氨酸酶
- Asparagine synthetase
- ATF/CREB proteins
- ATP Citrate Lyase/ATP柠檬酸裂解酶
- BBOX
- BDK
- Beta-glucuronidase
- Carbonic Anhydrase/碳酸酐酶
- Carboxylesterase
- Carboxypeptidase/羧肽酶
- Cardiolipin Peroxidase
- Cathepsin/组织蛋白酶
- Ceramidase/神经酰胺酶
- CETP
- Cholesterol Transporter
- CPA
- CPSI
- Creatine kinase
- Cryptochrome
- CSE
- CYP51
- Cytochrome c oxidase
- D-amino acid oxidase
- D6D
- DAPA synthase
- Decarboxylase/脱羧酶
- Dehydrogenase/脱氢酶
- DGAT
- DGK
- Dopamine β-hydroxylase
- E-NTPDase
- Elastase/弹性蛋白酶
- Enolase/烯醇化酶
- Enteropeptidase
- ERAP
- FABP
- Factor Xa
- Farnesyl Transferase/法尼基转移酶
- FAS
- FBPase/二磷酸酶
- Ferroptosis/铁死亡
- FOXO
- FTO
- Fumarate hydratase
- FVII
- FXR
- G0/G1 switch protein 2
- Galactosidases
- GCN
- GCS
- GGTase
- Glucokinase/葡萄糖激酶
- Glucosidase/葡萄糖苷酶
- GLUT
- Glutaminase C
- Glutathione Reductase
- GOAT
- Glyoxalase
- GPx
- GSNOR
- GST
- Heme Oxygenase (HO)
- Hexokinase/己糖激酶
- HMGCR
- HPSE
- Hydrolase/水解酶
- Hydroxylase/羟化酶
- IDH
- IDO
- Ketohexokinase
- LDL
- LDLR
- Lipase/脂肪酶
- Lipoxygenase/脂氧合酶
- LOX
- LRH-1
- LXR
- MAGL
- MASTL
- MDH
- MetAP
- MGAT
- Mineralocorticoid Receptor/盐皮质激素受体
- Mitochondrial Electron Transport Chain
- Mitochondrial Metabolism/线粒体代谢
- MPC
- NAMPT
- Neprilysin/脑啡肽酶
- NNMT
- NPP
- NPR
- NQO
- OGT
- OPA1
- P448
- P450
- PAI-1
- PARG
- PDE
- PDHK
- PEPCK
- PGAM1
- PGC-1α
- PHGDH
- Phospholipase/磷脂酶
- PI5P4K
- PKM1
- PKM2
- Procollagen C Proteinase
- Proprotein convertases
- Pyruvate Kinase/丙酮酸激酶
- QR
- RAR/RXR
- RBP
- REV-ERB
- ROR
- SCD
- sEH
- SGK
- Sialyltransferase
- SHMT
- SLC25
- Sphingosine acyltransferase
- SQOR
- Srx
- Steroid Sulfatase
- TDO
- TGH
- Thioredoxin/硫氧还蛋白
- Thrombin凝血酶
- Transferase
- Transketolase/转酮酶
- TrxR
- Trypanothione reductase
- UGT
- VD/VDR
- Xanthine Oxidase/黄嘌呤氧化酶
- αKGD
Ubiquitin泛素化
- E3 Ligase
- DUB
- Proteasome
- E1 Activating
- p97
- SUMO
- E2 conjugating
Neuronal Signaling/神经信号
- 5-HT Receptor | 5-羟色胺受体
- AAK1
- AChE
- AChR
- Adenosine Kinase | 腺苷激酶
- Adrenergic Receptor | 肾上腺素能受体
- AMPAR
- Amyloid-β | 淀粉样蛋白-β
- Calcium Channel
- CaMK
- Cannabinoid Receptor | 大麻素受体
- CGRP Receptor | 降钙素基因相关肽受体
- Cholecystokinin Receptor | 缩胆囊素受体
- Cholinesterase
- CHT
- COMT
- DAT
- Dopamine Receptor | 多巴胺受体
- Endorphin
- Enkephalinase
- FAAH
- GABA Receptor | GABA受体
- GABA transporter
- Glucosylceramide Synthase | 葡萄糖神经酰胺合成酶
- GluR
- Glutamate Release
- GPR119
- GPR139
- GPR24
- GPR55
- Histamine Receptor | 组胺受体
- Huntingtin
- Imidazoline Receptor
- Kainate receptor
- MAO
- Melanocortin Receptor | 黑素皮质素受体
- mGluR
- MT Receptor
- NET
- Neuropeptide Y Receptor | 神经肽Y受体
- Neurotensin Receptor | 神经降压素受体
- NGF
- NK Receptor
- NMDA
- NMDAR
- Notch
- Nurr1
- OLIG2
- Opioid Receptor | 阿片受体
- OX Receptor
- P2X Receptor | P2X受体
- PSD-95
- QC
- RAGE
- REST
- Ryanodine Receptor-1
- S100β
- Secretase
- SERT
- Sigma Receptor
- SMS
- SSRIs
- Substance P
- TAAR
- Tau Protein | Tau蛋白
- TLX
- Trk Receptor | Trk受体
- TRP Channel | TRP通道
- TTR
- α-synuclein | α-突触核蛋白
- COX
NF-κB信号通路
- IKK
- MALT1
- NF-κB
- Nrf2
- Pirin
- RANKL
- RANKL/RANK
- RIP kinase | RIP激酶
- TAK1
GPCR & G蛋白
- Adrenergic Receptor
- AChR
- 5-HT Receptor
- Histamine Receptor
- Dopamine Receptor
- Ras
- K-Ras
- GPR
- Prostaglandin Receptor
- GluR
- Adenosine Receptor
- P2 Receptor
- CXCR
- CCR
- Angiotensin Receptor
- S1P Receptor
- Hedgehog/Smoothened
- Cannabinoid Receptor
- PKA
- SGLT
- Opioid Receptor
- cAMP
- Glucagon Receptor
- Sigma Receptor
- PAR
- Endothelin Receptor
- Neurokinin Receptor
- LTR
- LPA Receptor
- PKG
- Guanylate Cyclase
- OX Receptor
- GPCR19
- Platelet aggregation
- GTPase
- Vasopressin Receptor
- CGRP Receptor
- FPR
- Adenylyl Cyclase
- CCK receptor
- MT Receptor
- AdipoR
- PKD
- Taste Receptor
- NPY receptor
- Melanocortin Receptor
- Apelin receptor
- GLP-1 Receptor
- GHSR
- Oxytocin Receptor
- GRK
- CaSR
- Bradykinin Receptor
- Arrestin
- Leukotriene
- DOCK
- Imidazoline Receptor
- TSH Receptor
- TAAR
- Orphan Receptor
- GNRH Receptor
- MCHR
- PAFR
- CRFR
- RXFP receptor
- RGS
Endocrinology & Hormones/内分泌&激素
- 5-alpha Reductase | 5-alpha还原酶
- ACE
- Adrenergic Receptor | 肾上腺素能受体
- Androgen Receptor | 雄激素受体
- Aromatase | 芳香酶
- ERR
- GHSR
- Glucocorticoid Receptor | 糖皮质激素受体
- GNRH Receptor | GNRH受体
- Mineralocorticoid Receptor | 盐皮质激素受体
- Opioid Receptor | 阿片受体
- Progesterone Receptor | 孕酮受体
- PTGR
- PTHR
- Renin
- Sepiapterin reductase
- SSTR
- Taste receptor
- Thyroid Hormone Receptor | 甲状腺激素受体
- TPO
- TRHR
- TSH Receptor | 促甲状腺激素受体
Transmembrane Transporters/跨膜转运
- ABC Transporter
- AKK1
- ANT
- AQP
- AQP3
- ARF
- ATP Synthase | ATP合成酶
- ATPase
- BCRP
- Calcium Channel 钙离子通道
- CFTR
- Chloride Channel | 氯离子通道
- CRAC Channel | CRAC通道
- CRM1
- EAAT
- Efflux pump
- ENT
- Ferroportin
- GABA Receptor | GABA受体
- GLUT
- Glutamate transporter
- Glycine transporter
- HCN Channel | HCN通道
- IBAT
- MAT
- MCT
- Na+/Ca2+ Exchanger
- Na+/K+ ATPase
- Na/HCO3 cotransporter
- NKCC
- Oct
- OCTN
- Organic Anion Transporter
- P-gp
- P2X Receptor | P2X受体
- Piezo
- Potassium Channel | 钾通道
- Proton Pump | 质子泵
- SEO1
- SGLT
- SLC
- Sodium Channel | 钠通道
- SV2
- TRP Channel | TRP通道
- UCP
- URAT1
- Urea Transporter
- VDAC
- VRAC
Proteases蛋白酶
- HDAC
- Caspase
- MMP
- HCV Protease
- Cysteine Protease
- HIV Protease
- Tyrosinase
- DPP
- Proteasome
- Serine Protease
- Secretase
- Acyltransferase
- Glutaminase
- Thrombin
- Cathepsin B
- PCSK9
- Carboxypeptidase
- PREP
- PAD
- Neprilysin
- SGK
- MALT
- Aminopeptidase
- 3C-Like Protease
- GOT
- PSMA
- PGDS
Microbiology微生物
- Bacterial
- Antibiotics
- Anti-infection
- Fungal
- Antiviral
- COVID-19
- Parasite
- Reverse
- Transcriptase
- HIV
- HCV Protease
- HIV Protease
- ribosome
- SARS-CoV
- Influenza Virus
- β-lactamase
- Integrase
- HBV
- CMV
- HCV
- Neuraminidase
- HSV
- Thioredoxin Reductase
- Enterovirus
- RSV
- DprE1
- 3C-Like Protease
- Ribosomal Peptidyl Transferase
- HPV
Others
- Others
- Dyes
- Antineoplastic and Immunosuppressive Antibiotics
- ADC Cytotoxin
- Selection Antibiotics for Transfected Cell
- PROTAC
- Antibiotics for Mammalian Cell Culture
- ADC Linker
- Molecular Glues
- Antibiotics for Plant Cell Culture
- PROTAC Linker
- Hydrotropic Agents
- E3 ligase Ligand
- Target Protein Ligand
- Antibody-Drug Conjugate
- Drug-Linker Conjugates for ADC
- Chelating Agent
- Surfactant
- Enzyme Substrate

Lobetyolin 党参炔苷 CAS#129277-38-9 目录号D809488

￥1080.00

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