• 生物活性

靶点及简介 ：PDE4 inhibitor, orally active

YM976是一种磷酸二酯酶4(PDE4)抑制剂,IC50为2.2 nM。YM976表明抗炎活性与呕吐作用分离,并抑制抗原诱导的气道反应。

• 验证及参考文献

验证：

参考文献：

[1] Salim Megat, et al. Antiallodynic action of phosphodiesterase inhibitors in a mouse model of peripheral nerve injury

[2] Will McDonough, et al. PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice

[3] J Mokr, et al. Effects of Selective Inhibition of PDE4 by YM976 on Airway Reactivity and Cough in Ovalbumin-Sensitized Guinea Pigs

[4] Simon F Crowe, et al. The type 4 phosphodiesterase inhibitors rolipram and YM976 facilitate recall of the weak version of the passive avoidance task in the day-old chick

[5] Satoshi Yamamoto, et al. The effects of a novel phosphodiesterase 7A and -4 dual inhibitor, YM-393059, on T-cell-related cytokine production in vitro and in vivo

• 溶解度及制备方案

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.1869 mL	15.9347 mL	31.8695 mL
5 mM	0.6374 mL	3.1869 mL	6.3739 mL
10 mM	0.3187 mL	1.5935 mL	3.1869 mL

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