• 生物活性

靶点及简介 ：LB-100 is a small-molecular protein phosphatase 2A(PP2A)inhibitor with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.

LB-100是一种水溶性的丝氨酸/苏氨酸蛋白磷酸酶2A（PP2A）抑制剂，在BxPc-3和Panc-1细胞中，IC50值分别为0.85 μM和3.87 μM。同时还能上调参与脂肪酸β氧化的蛋白（如PPARα、PPARγ辅激活因子-1α (PGC-1α)、CPT 1α、ACOX1和UCP2）水平。此外，LB-100还能显著改善HFD诱导的小鼠肥胖、肝脏脂质积聚和肝损伤。

细胞实验：
LB-100 showed dose-dependent inhibition of cell growth in both cell lines. The IC50 of LB-100 was 0.85 μM and 3.87 μM in BxPc-3 and Panc-1, respectively. While the IC50 of doxorubicin was 2.3 μM and 1.7 μM in BxPc-3 and Panc-1, respectively, LB-100 did not synergize with doxorubicin in both cell lines.

动物实验：

LB-100 synergistically enhanced the activity of doxorubicin in vivo. This effect was associated with increased microvessel density, blood perfusion, and doxorubicin concentrations within the xenografts.

• 验证及参考文献

参考文献：
LB-100 synergistically enhanced the activity of doxorubicin in vivo. This effect was associated with increased microvessel density, blood perfusion, and doxorubicin concentrations within the xenografts.

• 溶解度及制备方案
  

  
  

  	Solvent	Max Conc. mg/mL	Max Conc. mM
  Solubility
  	DMSO	54.0	201.26

  
  
  

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.73 mL	18.63 mL	37.27 mL
5 mM	0.75 mL	3.73 mL	7.45 mL
10 mM	0.37 mL	1.86 mL	3.73 mL
50 mM	0.07 mL	0.37 mL	0.75 mL



关键词：LB-100, CAS# 1632032-53-1, LB-100供应商, PPAR抑制剂, 购买LB-100, LB-100溶解度, LB-100结构式