• 生物活性

靶点及简介 ：

MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP readily penetrates the blood-brain barrier and is moderately effective in suppressing progression of intracerebral glioblastoma xenografts.

MOMIPP是一种大细胞增殖诱导剂,是一种PIKfyve抑制剂。MOMIPP穿透血脑屏障(BBB)。

• 验证及参考文献

验证：

参考文献：

[1]. Margaux Colin, et al. Dysregulation of Macropinocytosis Processes in Glioblastomas May Be Exploited to Increase Intracellular Anti-Cancer Drug Levels: The Example of Temozolomide. Cancers (Basel). 2019 Mar 22;11(3):411.

[2]. Zehui Li, et al. The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma. BMC Cancer. 2019 Jan 16;19(1):77.

• 溶解度及制备方案

• DMSO	15 mg/mL (51.31 mM)
  Ethanol	Insoluble
  Water	Insoluble

  
  

Preparing Stock Solutions

Concentration/Volume/ Mass	1 mg	5 mg	10 mg
1 mM	3.4208 mL	17.1040 mL	34.2079 mL
5 mM	0.6842 mL	3.4208 mL	6.8416 mL
10 mM	0.3421 mL	1.7104 mL	3.4208 mL
50 mM	0.0684 mL	0.3421 mL	0.6842 mL

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