• 生物活性

靶点及简介 ：KV11.1 (hERG) channels blocker

E-4031是抗心律失常剂苯磺酰胺，阻断ATP敏感性钾通道。三类抗心律失常药，可阻滞hERG型钠离子通道。

E-4031 selectively blocks hERG K⁺ channels.

• 验证及参考文献

验证：

参考文献：

[1] Fumiya Tamura, et al. The Effect of a Synthetic Estrogen, Ethinylestradiol, on the hERG Block by E-4031

[2] Idit Goldfracht, et al. Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications

[3] Mohammed R Nikmaram, et al. Characterization of the effects of ryanodine, TTX, E-4031 and 4-AP on the sinoatrial and atrioventricular nodes

[4] No authors listed. Drugs R D. E 4031

[5] J R Clay, et al. A review of the effects of three cardioactive agents on the electrical activity from embryonic chick heart cell aggregates: TTX, ACh, and E-4031

• 溶解度及制备方案

Water	48 mg/mL   (101.17 mM)
DMSO	30 mg/mL   (63.23 mM)
Ethanol	Insoluble

制备储备液

浓度    溶剂体积   质量	1 mg	5 mg	10 mg
1 mM	2.1077 mL	10.5387 mL	21.0775 mL
5 mM	0.4215 mL	2.1077 mL	4.2155 mL
10 mM	0.2108 mL	1.0539 mL	2.1077 mL
50 mM	0.0422 mL	0.2108 mL	0.4215 mL

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