• 生物活性

靶点及简介 ：

6-Methylcoumarin (Toncarine), a synthetic fragrance widely used in cosmetics, belongs to the class of organic compounds known as coumarins and derivatives.

6-Methylcoumarin是一种广泛用于化妆品的合成香料。

体外研究：

Transport experiments with Caco-2 cells show that 6-Methylcoumarin presents high permeability at all concentrations evaluated. This finding suggests that 6-Methylcoumarin could be transported across the gut wall by passive diffusion[1].

体内研究

    The plasma concentration-time curve shows that the maximum concentration (Cmax) is 17.13 ± 2.90 µg/mL at maximum time (Tmax) of 30 min for the oral route (200 mg/kg) and Cmax 26.18 ± 2.47 µg/mL at 6.0 min for the intraperitoneal administration (200 mg/kg), with elimination constant of (Ke) 0.0070/min and a short life half time of (T1/2) lower that 120 min. 6-Methylcoumarin has high accumulation in the liver, and widespread distribution in all the organs evaluated. The oral bioavailability (F) of 6-Methylcoumarin is 45% in Wistar rats[1].

• 验证及参考文献

验证：

参考文献：

• [1] PA Cárdenas, et al. Braz J Pharm Sci. 2017, 53(1)

• 溶解度及制备方案

DMSO	32 mg/mL  (199.79 mM)

制备储备液

浓度   溶剂体积    质量	1 mg	5 mg	10 mg
1 mM	6.2434 mL	31.2168 mL	62.4337 mL
5 mM	1.2487 mL	6.2434 mL	12.4867 mL
10 mM	0.6243 mL	3.1217 mL	6.2434 mL
50 mM	0.1249 mL	0.6243 mL	1.2487 mL

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