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首页 Research Grade Biosimilar Therapeutic Antibodies Omalizumab(anti-IgE),Olizumab, rhuMab-E25,奥马珠单抗 (CAS#242138-07-4 目录号D802044)
Omalizumab 奥马珠单抗是一种结合免疫球蛋白E(IgE)的人源化IgG1κ单抗,其可阻断IgE介导的过敏级联反应,减少炎症因子释放。

规格 价格 库存 数量
2mg ¥ 6559.00 100
5mg ¥ 9158.00 100
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概述
别名 Olizumab, rhuMab-E25,奥马珠单抗
产品名 Omalizumab
CAS号 242138-07-4
目录号 D802044
化学式 C₆₄₅₀H₉₉₁₆N₁₇₁₄O₂₀₂₃S₃₈
分子量 145056.09
溶解度 PBS Buffer, PH 7.4
靶点 anti-IgE
储存条件 Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.
用途 仅供科学研究使用!不能用于人体及动物治疗
纯度 >98%
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详情
  • 生物活性


靶点及简介 :Omalizumab 奥马珠单抗是一种结合免疫球蛋白E(IgE)的人源化IgG1κ单抗,其可阻断IgE介导的过敏级联反应,减少炎症因子释放。

Omalizumab (anti-IgE)是一种针对人免疫球蛋白 E (IgE)的重组人源化单克隆抗体,KD 为 0.393 nM。Omalizumab (anti-IgE)与人 FcγRIIb 受体结合的 KD 为 6.37 uM。


Omalizumab is a recombinant DNA-derived humanized IgG1k monoclonal antibody that specifically binds to free human immunoglobulin E (IgE) in the blood and interstitial fluid and to membrane-bound form of IgE (mIgE) on the surface of mIgE-expressing B lymphocytes. Omalizumab inhibits the binding of IgE to FcεRI on mast cells and basophils by binding to an antigenic epitope on IgE that overlaps with the site to which FcεRI binds. When IgE is bound to the receptor, the antigenic epitope on IgE to which omalizumab binds is sterically hindered by the receptor and is not accessible to omalizumab binding, thus averting the anaphylactic effects presumably unavoidable with an ordinary anti-IgE antibody . Furthermore, although the peptide elements on IgE involved in binding to low affinity IgE receptor (FcεRII) on many cell types are different from the peptide elements involved in binding to FcεRI, omalizumab, by steric hindrance, also prevents binding of IgE to FcεRII.


体内研究

Omalizumab (anti-IgE) is effective in controlling the allergic symptoms of allergic rhinitis by lowering inflammatory mediator CysLT levels of nasal lavage in an experimental allergic rhinitis mode.



  • 验证及参考文献


验证:

参考文献:

[1] Chang TW, et al. Adv Immunol. Anti-IgE antibodies for the treatment of IgE-mediated allergic diseases.

[2] Schulman ES. Am J Respir Crit Care Med. Development of a monoclonal anti-immunoglobulin E antibody (omalizumab) for the treatment of allergic respiratory disorders.


  • 溶解度及制备方案
    Concentration / Solvent Volume / Mass1 mg5 mg10 mg
    1 mM0.0069 mL0.0345 mL0.0689 mL
    5 mM0.0014 mL0.0069 mL0.0138 mL
    10 mM0.0007 mL0.0034 mL0.0069 mL

请将产品保持在 -20°C 以下以进行长期储存。


不用于人类、兽医诊断或治疗用途。


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