• 生物活性

靶点及简介 ：MrgprX2 antagonist-5 是一种靶向 MrgprX2 的拮抗剂，适用于皮肤炎症性疾病研究，相关信息见专利 WO2020223255A1 中化合物 16。MrgprX2拮抗剂-5可用于皮肤炎症性疾病的研究。

体外研究

    MRGPRX2是Mas相关基因家族的一员,被发现在感觉神经元、肥大细胞和最近的角质形成细胞中表达。MRGPRX2 mRNA存在于脂肪组织、食道、膀胱、肺中,在皮肤中含量最高。MRGPRX2的激活导致肥大细胞脱颗粒,随后出现假性过敏反应。

MRGPRX2, a member of the Mas-related gene family, was found to be expressed in sensory neurons, mast cells and, most recently, in keratinocytes. MRGPRX2 mRNA is present in adipose tissue, esophagus, urinary bladder, lungs with the highest levels found in skin. Activation of MRGPRX2 leads to mast cell degranulation with subsequent pseudo-allergic reactions.

• 验证及参考文献

参考文献：

[1]. BIGI S, et, al. 3-amino-4h-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives as inhibitors of mrgx2. WO2020223255A1.

[2]. Porebski G, et, al. Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions. Front Immunol. 2018 Dec 20;9:3027.

制备储备液

关键词: MrgprX2 antagonist-5 | 2527815-74-1 | Mas-related G-protein-coupled Receptor (MRGPR) | MrgprX2 | MrgprX2 Antagonist | GPCR/G Protein | Mas-related G-protein-coupled Receptor (MRGPR) | 仅供科研使用 | DKM-信号通路专用抑制剂 | MrgprX2 antagonist-5 纯度/质量文件 | MrgprX2 antagonist-5 实验方案 | MrgprX2 antagonist-5 技术信息