| 产品名 | Aripiprazole |
| CAS号 | 129722-12-9 |
| 目录号 | D910117 |
| 化学式 | C₂₃H₂₇Cl₂N₃O₂ |
| 分子量 | 448.39 |
| 溶解度 | ≥ 22.4mg/mL in DMSO |
| 靶点 | 5-HT receptor partial agonist |
| 储存条件 | Store at RT |
| 用途 | 仅供科学研究使用!不能用于人体及动物治疗 |
靶点及简介 ：5-HT receptor partial agonist
Aripiprazole has been found to be a dopamine-serotonin system stabilizer with potent partial agonist activity at dopamine D2 and 5-HT1A receptors and antagonist activity at 5-HT2A receptors. In addition, aripiprazole has been reported to label with the agonist [125I]7-OH-PIPAT and with the antagonist [3H]spiperone with 0.34±0.02nM and 0.70±0.22nM, respectively. Besides, aripiprazole has been revealed to dose-dependently and potently inhibit the increase in cAMP accumulation stimulated by forskolin in CHO cells and HEK-293 cells. Other results have also been reported that aripiprazole completely inhibited the increase GTPase activity stimulated by the D2 receptor agonist quinpirole in rat striatal membranes [1].
体外研究：
体内研究：
验证：
参考文献：
[1] Burris KD1, Molski TF, Xu C, Ryan E, Tottori K, Kikuchi T, Yocca FD, Molinoff PB. Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors. J Pharmacol Exp Ther. 2002 Jul; 302(1):381-9.
DMSO: 44.8 mg/mL (100 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
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