DKM活性分子 Decode Key Molecules 活性化合物活性分子平台 7*24在线

DKM活性分子 Detect・Discover・Decode Key Molecules —— 活性分子平台 | 7×24 在线 ☎️400-168-1698 📩info@dkm.cn

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DKM活性化合物

荧光素衍生物AkaLumine盐酸盐（CAS#2558205-28-8）对重组萤火虫荧光素酶（Fluc）的米氏常数（Km）为2.06 μM；其近红外发光特性赋予优异的组织穿透能力，大幅增强成像信噪比，从而实现活体动物模型中极低给药剂量下的高灵敏度、非侵入式生物发光动态追踪。

AkaLumine盐酸盐是荧光素类似物，Km为2.06 μM，具近红外发射峰，支持深层组织成像，提升检测灵敏度，实现动物模型中低浓度、高精度、非侵入性生物发光成像。

DKM活性化合物 6天前

15980

DKM活性化合物

Ceralasertib (AZD6738)：靶向ATR激酶的选择性抑制剂 CAS号：1352226-88-0

AZD6738是高效ATR激酶抑制剂（IC50=1 nM），可诱导肿瘤细胞凋亡、周期阻滞及衰老，增强顺铂等化疗药效，尤其在ATM缺陷型肺癌中表现显著协同作用。

DKM活性化合物 6天前

14681

DKM活性化合物

DKM类器官培养核心小分子试剂全指南｜精挑优选，高效可靠，建议长期保存！

小分子化合物可穿透细胞膜、靶点多样，广泛用于类器官培养中调控信号通路、抑制凋亡、促进分化及维持功能，显著提升其存活率、稳定性与生理相关性。

DKM活性化合物 1周前

5104

DKM活性化合物

现货供应，高纯度苯乙酰辅酶A（Phenylacetyl CoA），CAS 7532-39-0：抗生素生物合成与环境污染物靶向降解的关键代谢枢纽；依托CRISPR精准编辑与理性酶工程，其工业化稳定性与功能可塑性大幅提升，正快速支撑新药创制、生态修复与低碳农业三大战略方向。

苯乙酰辅酶A为高纯度现货，参与关键合成代谢，广泛用于生化研究及药物开发。

DKM活性化合物 1周前

19610

DKM活性化合物

生物药与大分子强势崛起，小分子药物是否已步入黄昏，真日薄西山了？

小分子药物仍是全球医药市场基石，2025年占TOP100药品销售额超60%，FDA新药中占比达73.9%，中国Ⅰ类创新药占比回升至61.8%，CDMO业务稳健增长。小分子从未退场，未来也永远不会退场。

DKM活性化合物 1周前

2467

DKM活性化合物

细胞因子（Cytokine, CK）：功能解析、作用机理及检测策略（附52 种细胞因子总结表）

细胞因子（cytokine, CK）是免疫系统中关键的信使分子，由免疫及非免疫细胞分泌，具多效性、重叠性等特性，参与抗感染、炎症调控及疾病发生发展。附52 种细胞因子总结表。

DKM活性化合物 2周前

3686

DKM资讯

全部

PI3K/Akt/mTOR
- Akt
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- ATM/ATR
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- PI4K
- PIKfyve
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- PTEN
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Epigenetics
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- Histone Acetyltransferase/组蛋白乙酰转移酶
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- JAK
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Angiogenesis
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Apoptosis/凋亡
- Apoptosis related/凋亡相关
- Ras
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Autophagy/自噬
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ER stress & UPR/内质网应激&UPR响应
- Antioxidant
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MAPK
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Cytoskeletal Signaling细胞骨架
- Akt
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- Integrin
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- Dynamin
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- Gap-Junction
- Cardiac Myosin
- TACC3
- Piezo Channel
- Myosin
- Tight Junction Protein
Cell Cycle细胞周期
- DNA/RNA Synthesis
- CDK
- Ras
- Microtubule Associated
- K-Ras
- HSP
- Aurora Kinase
- Casein Kinase
- Serine/threonin kinase
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- PAK
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- LIM kinase
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- Cell Cycle Arrest
- Haspin Kinase
- DOCK
- TACC3
- CDK4/6
- APC
- FOXM1
- Cyclin
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- Mad2
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TGF-beta/Smad
- PKC
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- Bcr-Abl
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DNA Damage/DNA Repair/DNA损伤/修复
- DNA/RNA Synthesis
- HDAC
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- Sirtuin
- Casein Kinase
- ATM/ATR
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- DNA alkylator
- DHFR
- Nucleoside Analog/Antimetabolite
- eIF
- Telomerase
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- BMI-1
- LIM kinase
- OGG1
- MTH1
- G-quadruplex
- High-mobility Group
- FENs
- SMN
- Pax
- WRN
Stem Cells & Wnt/干细胞&Wnt通路
- JAK
- STAT
- ERK
- Wnt/beta-catenin
- TGF-beta/Smad
- GSK-3
- Casein Kinase
- ROCK
- Hedgehog/Smoothened
- PKA
- Notch
- Secretase
- PORCN
- OCT
- KLF
- Fascin
- Stemness kinase
- SFRP
Hippo
- TEAD
- YAP
- MAP4K
- LATS
- MST
Metabolism代谢
- 11β-HSD
- 15-PGDH
- 2OG Oxygenase
- 3-PGDH
- 3MST
- 6PGD
- ACAT
- ACC
- Acetolactate Synthase
- ACMSD
- Aconitate hydratase
- ACS
- Adenosine Deaminase/腺苷脱氨酶
- Adenosylhomocysteinase
- ADP-ribosyltransferase
- AhR
- AKR
- ALDH
- Aldose Reductase/醛糖还原酶
- Aminopeptidase/氨肽酶
- Antifolate/抗叶酸
- AO
- ApoE
- Arginase/精氨酸酶
- Asparagine synthetase
- ATF/CREB proteins
- ATP Citrate Lyase/ATP柠檬酸裂解酶
- BBOX
- BDK
- Beta-glucuronidase
- Carbonic Anhydrase/碳酸酐酶
- Carboxylesterase
- Carboxypeptidase/羧肽酶
- Cardiolipin Peroxidase
- Cathepsin/组织蛋白酶
- Ceramidase/神经酰胺酶
- CETP
- Cholesterol Transporter
- CPA
- CPSI
- Creatine kinase
- Cryptochrome
- CSE
- CYP51
- Cytochrome c oxidase
- D-amino acid oxidase
- D6D
- DAPA synthase
- Decarboxylase/脱羧酶
- Dehydrogenase/脱氢酶
- DGAT
- DGK
- Dopamine β-hydroxylase
- E-NTPDase
- Elastase/弹性蛋白酶
- Enolase/烯醇化酶
- Enteropeptidase
- ERAP
- FABP
- Factor Xa
- Farnesyl Transferase/法尼基转移酶
- FAS
- FBPase/二磷酸酶
- Ferroptosis/铁死亡
- FOXO
- FTO
- Fumarate hydratase
- FVII
- FXR
- G0/G1 switch protein 2
- Galactosidases
- GCN
- GCS
- GGTase
- Glucokinase/葡萄糖激酶
- Glucosidase/葡萄糖苷酶
- GLUT
- Glutaminase C
- Glutathione Reductase
- GOAT
- Glyoxalase
- GPx
- GSNOR
- GST
- Heme Oxygenase (HO)
- Hexokinase/己糖激酶
- HMGCR
- HPSE
- Hydrolase/水解酶
- Hydroxylase/羟化酶
- IDH
- IDO
- Ketohexokinase
- LDL
- LDLR
- Lipase/脂肪酶
- Lipoxygenase/脂氧合酶
- LOX
- LRH-1
- LXR
- MAGL
- MASTL
- MDH
- MetAP
- MGAT
- Mineralocorticoid Receptor/盐皮质激素受体
- Mitochondrial Electron Transport Chain
- Mitochondrial Metabolism/线粒体代谢
- MPC
- NAMPT
- Neprilysin/脑啡肽酶
- NNMT
- NPP
- NPR
- NQO
- OGT
- OPA1
- P448
- P450
- PAI-1
- PARG
- PDE
- PDHK
- PEPCK
- PGAM1
- PGC-1α
- PHGDH
- Phospholipase/磷脂酶
- PI5P4K
- PKM1
- PKM2
- Procollagen C Proteinase
- Proprotein convertases
- Pyruvate Kinase/丙酮酸激酶
- QR
- RAR/RXR
- RBP
- REV-ERB
- ROR
- SCD
- sEH
- SGK
- Sialyltransferase
- SHMT
- SLC25
- Sphingosine acyltransferase
- SQOR
- Srx
- Steroid Sulfatase
- TDO
- TGH
- Thioredoxin/硫氧还蛋白
- Thrombin凝血酶
- Transferase
- Transketolase/转酮酶
- TrxR
- Trypanothione reductase
- UGT
- VD/VDR
- Xanthine Oxidase/黄嘌呤氧化酶
- αKGD
Ubiquitin泛素化
- E3 Ligase
- DUB
- Proteasome
- E1 Activating
- p97
- SUMO
- E2 conjugating
Neuronal Signaling/神经信号
- 5-HT Receptor | 5-羟色胺受体
- AAK1
- AChE
- AChR
- Adenosine Kinase | 腺苷激酶
- Adrenergic Receptor | 肾上腺素能受体
- AMPAR
- Amyloid-β | 淀粉样蛋白-β
- Calcium Channel
- CaMK
- Cannabinoid Receptor | 大麻素受体
- CGRP Receptor | 降钙素基因相关肽受体
- Cholecystokinin Receptor | 缩胆囊素受体
- Cholinesterase
- CHT
- COMT
- DAT
- Dopamine Receptor | 多巴胺受体
- Endorphin
- Enkephalinase
- FAAH
- GABA Receptor | GABA受体
- GABA transporter
- Glucosylceramide Synthase | 葡萄糖神经酰胺合成酶
- GluR
- Glutamate Release
- GPR119
- GPR139
- GPR24
- GPR55
- Histamine Receptor | 组胺受体
- Huntingtin
- Imidazoline Receptor
- Kainate receptor
- MAO
- Melanocortin Receptor | 黑素皮质素受体
- mGluR
- MT Receptor
- NET
- Neuropeptide Y Receptor | 神经肽Y受体
- Neurotensin Receptor | 神经降压素受体
- NGF
- NK Receptor
- NMDA
- NMDAR
- Notch
- Nurr1
- OLIG2
- Opioid Receptor | 阿片受体
- OX Receptor
- P2X Receptor | P2X受体
- PSD-95
- QC
- RAGE
- REST
- Ryanodine Receptor-1
- S100β
- Secretase
- SERT
- Sigma Receptor
- SMS
- SSRIs
- Substance P
- TAAR
- Tau Protein | Tau蛋白
- TLX
- Trk Receptor | Trk受体
- TRP Channel | TRP通道
- TTR
- α-synuclein | α-突触核蛋白
- COX
NF-κB信号通路
- IKK
- MALT1
- NF-κB
- Nrf2
- Pirin
- RANKL
- RANKL/RANK
- RIP kinase | RIP激酶
- TAK1
GPCR & G蛋白
- Adrenergic Receptor
- AChR
- 5-HT Receptor
- Histamine Receptor
- Dopamine Receptor
- Ras
- K-Ras
- GPR
- Prostaglandin Receptor
- GluR
- Adenosine Receptor
- P2 Receptor
- CXCR
- CCR
- Angiotensin Receptor
- S1P Receptor
- Hedgehog/Smoothened
- Cannabinoid Receptor
- PKA
- SGLT
- Opioid Receptor
- cAMP
- Glucagon Receptor
- Sigma Receptor
- PAR
- Endothelin Receptor
- Neurokinin Receptor
- LTR
- LPA Receptor
- PKG
- Guanylate Cyclase
- OX Receptor
- GPCR19
- Platelet aggregation
- GTPase
- Vasopressin Receptor
- CGRP Receptor
- FPR
- Adenylyl Cyclase
- CCK receptor
- MT Receptor
- AdipoR
- PKD
- Taste Receptor
- NPY receptor
- Melanocortin Receptor
- Apelin receptor
- GLP-1 Receptor
- GHSR
- Oxytocin Receptor
- GRK
- CaSR
- Bradykinin Receptor
- Arrestin
- Leukotriene
- DOCK
- Imidazoline Receptor
- TSH Receptor
- TAAR
- Orphan Receptor
- GNRH Receptor
- MCHR
- PAFR
- CRFR
- RXFP receptor
- RGS
Endocrinology & Hormones/内分泌&激素
- 5-alpha Reductase | 5-alpha还原酶
- ACE
- Adrenergic Receptor | 肾上腺素能受体
- Androgen Receptor | 雄激素受体
- Aromatase | 芳香酶
- ERR
- GHSR
- Glucocorticoid Receptor | 糖皮质激素受体
- GNRH Receptor | GNRH受体
- Mineralocorticoid Receptor | 盐皮质激素受体
- Opioid Receptor | 阿片受体
- Progesterone Receptor | 孕酮受体
- PTGR
- PTHR
- Renin
- Sepiapterin reductase
- SSTR
- Taste receptor
- Thyroid Hormone Receptor | 甲状腺激素受体
- TPO
- TRHR
- TSH Receptor | 促甲状腺激素受体
Transmembrane Transporters/跨膜转运
- ABC Transporter
- AKK1
- ANT
- AQP
- AQP3
- ARF
- ATP Synthase | ATP合成酶
- ATPase
- BCRP
- Calcium Channel 钙离子通道
- CFTR
- Chloride Channel | 氯离子通道
- CRAC Channel | CRAC通道
- CRM1
- EAAT
- Efflux pump
- ENT
- Ferroportin
- GABA Receptor | GABA受体
- GLUT
- Glutamate transporter
- Glycine transporter
- HCN Channel | HCN通道
- IBAT
- MAT
- MCT
- Na+/Ca2+ Exchanger
- Na+/K+ ATPase
- Na/HCO3 cotransporter
- NKCC
- Oct
- OCTN
- Organic Anion Transporter
- P-gp
- P2X Receptor | P2X受体
- Piezo
- Potassium Channel | 钾通道
- Proton Pump | 质子泵
- SEO1
- SGLT
- SLC
- Sodium Channel | 钠通道
- SV2
- TRP Channel | TRP通道
- UCP
- URAT1
- Urea Transporter
- VDAC
- VRAC
Proteases蛋白酶
- HDAC
- Caspase
- MMP
- HCV Protease
- Cysteine Protease
- HIV Protease
- Tyrosinase
- DPP
- Proteasome
- Serine Protease
- Secretase
- Acyltransferase
- Glutaminase
- Thrombin
- Cathepsin B
- PCSK9
- Carboxypeptidase
- PREP
- PAD
- Neprilysin
- SGK
- MALT
- Aminopeptidase
- 3C-Like Protease
- GOT
- PSMA
- PGDS
Microbiology微生物
- Bacterial
- Antibiotics
- Anti-infection
- Fungal
- Antiviral
- COVID-19
- Parasite
- Reverse
- Transcriptase
- HIV
- HCV Protease
- HIV Protease
- ribosome
- SARS-CoV
- Influenza Virus
- β-lactamase
- Integrase
- HBV
- CMV
- HCV
- Neuraminidase
- HSV
- Thioredoxin Reductase
- Enterovirus
- RSV
- DprE1
- 3C-Like Protease
- Ribosomal Peptidyl Transferase
- HPV
Others
- Others
- Dyes
- Antineoplastic and Immunosuppressive Antibiotics
- ADC Cytotoxin
- Selection Antibiotics for Transfected Cell
- PROTAC
- Antibiotics for Mammalian Cell Culture
- ADC Linker
- Molecular Glues
- Antibiotics for Plant Cell Culture
- PROTAC Linker
- Hydrotropic Agents
- E3 ligase Ligand
- Target Protein Ligand
- Antibody-Drug Conjugate
- Drug-Linker Conjugates for ADC
- Chelating Agent
- Surfactant
- Enzyme Substrate

4-Thiazolidinone, 2-[(2-chlorophenyl)imino],2-((2-氯苯基)氨基)噻唑-4(5H)-酮 CAS号 39130-93-3 目录号D100899

￥2380.00

DPPH ，1,1-二苯基-2-三硝基苯肼（DPPH）（CAS#1898-66-4 目录号D919475）

￥762.00

Dextran sulfate sodium salt，DSS; 葡聚糖硫酸钠盐（CAS#9011-18-1 目录号D919829)

￥500.00

Plicamycin,Mithramycin A ,光辉霉素（CAS#18378-89-7 目录号D915060）

￥1170.00

Seriniquinone（ CAS#22200-69-7 目录号D940363）

￥2280.00

α-Amyrin palmitate （CAS#22255-10-3 目录号D912843）

￥3250.00

Iodixanol，碘克沙醇（CAS#92339-11-2 目录号D805218）

￥650.00

Crustecdysone， β-蜕皮甾酮, Hydroxyecdysone, Ecdysterone, Commisterone, B-ecdysone, 20-Hydroxyecdysone CAS#5289-74-7 目录号D702881

￥1280.00

Furimazine (PBI 3939) （CAS#1374040-24-0 目录号D932913）

￥980.00

DFO，9H-1,8-Diazafluoren-9-one, 1,8-Diazafluoren-9-one （目录号D806849 ,CAS#54078-29-4）

￥737.00

WSP-1,Washington State Probe1,荧光探针WSP-1,hydrogen sulfide (H2S) fluorescent probe（CAS#1352750-34-5 目录号D945161）

￥707.00

Coelenterazine 400a ，Coelenterazine 400a; Bisdeoxycoelenterazine，腔肠素400a（CAS#70217-82-2 目录号D943290）

￥1559.00

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